CW September 2005

category image Volume 14
Issue Number 9
September 2005
ISSN 10593802

Doubling the Dose of Gleevec Overcomes Secondary Resistance in GIST

For patients with advanced gastrointestinal stromal tumors (GIST) with disease progression on the standard 400 mg daily dose of imatinib (Gleevec), a dose increase to 800 mg daily leads to further therapeutic activity. Overall toxicity after dose doubling remains easily manageable, with dose-reductions rarely necessary.
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Source & Additional Reading

J. Zalcberg et al., European Journal of Cancer, August 2005.

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