Germline mutations of the breast cancer-associated genes BRCA1 and 2 confer an increased risk of malignancy for life: ?familial? cancer; the finding of BRCA mutations may indicate an increased incidence of other cancers too. Since these cancers are the result (?) of discreet, but profound genetic alterations, it is to be expected that they are accompanied by characteristic morphological features of the tumor cells. However, these interrelationships, between sporadic breast cancer, BRCA loss of heterozygosity (LOH) and specific tumor morphology has only recently been evaluated and described.
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