CW September 2000
Volume 9Issue Number 9 September 2000 ISSN 10593802 Heat-Shock Proteins in Cancer: Time to ReconsiderAmong the many stress responses, the extended family of heat-shock proteins (HSPs) plays a controversial role in cancer. HSPs are an evolutionary conserved class of glycoproteins, constitutively expressed and/or inducible in all living cells. They maintain homeostasis when cells are exposed to various kinds of external stress and enable their survival from insults, such as heat, radiation and (unfortunately) chemotherapy. Various types of HSPs have been found in neoplasms and are used as tumor markers for prognostication; their modulation may perhaps improve current chemotherapeutical protocols.
Go to Previous Page Go to Next Page Source & Additional Reading A. M. Hurd et al., Heat Shock Protein 70 can modulate estrogen receptor a activity in breast cancer cells. Proc. Amer. Assoc. Cancer Research 41, 73, 2000. Purchase Downloadable Full-text PDF of Article: $10.00 Subscription is more cost effective than purchasing PDFs on-the-fly. Click here for details. Download Complete Issue CW September 2000Purchase Downloadable Full-text PDF of Complete Issue: $20.00 |
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