CW September 2000

category image Volume 9
Issue Number 9
September 2000
ISSN 10593802

Drugs and Genes Give Effective Therapeutic Synergy

Gene therapy has had a lot of bad press recently due to patient death in clinical trials for rare genetic diseases. However, a recent report of promising results from a Phase II Study has given renewed optimism to those using gene therapy to develop treatments for cancer. The development of novel oncolytic viruses presents an attractive gene delivery system which offers both selectivity and efficiency. Combining gene therapy with more conventional chemotherapy creates powerful synergy in treating cancer patients.
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Matthew D Weitzman, Ph.D.
Jonathan B Weitzman, Ph.D.

Khuri et al., A Controlled Trial of Intratumoral ONYX-015, A Selectively-replicating Adenovirus, in Combination with Cisplatin and 5-fluorouracil in Patients with Recurrent Head and Neck Cancer. Nature Medicine 6: 879-885 (2000).

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