Vitamins have still not lost their ?sex appeal?. Scores of researchers continue to publish scores of papers and are obviously able to generate support for vitamin studies, even from the NCI. Vitamin E is such a die-hard example. It started with guesswork about its function and blossomed to its acceptance as a panacea ? preventing everything from cataracts to aging; it was eventually demoted to just another health food additive. After a brief, optimistic period when tocopherols were seriously studied as preventive in respiratory cancer, a series of badly designed clinical trials cut short the initial promises. However, there is growing new understanding of the effects and mechanisms of action of some vitamin E derivatives which indicates that apart from their antioxidative properties, some may act not only as chemopreventive, but also as chemotherapeutic agents in cancer.
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