One of the causes of cancer-related bone pain is the dissolution of bone (osteolysis). Bone resorption produces acidic condition that stimulates certain nerve endings and causes pain. Endogenous protein molecules binding to surface receptors stimulate osteoclasts, a type of bone cells, engaged in bone resorption. Osteoprotegerin, a decoy receptor has been identified to inhibit osteoclast activity and tumor-induced bone pain.
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