It has become general practice to express scientific results, opinions and even theories in a colorless, neutral style: ?it appears???it seems???it has been found??. After over thirty years in the equally frustrating and fascinating business of oncology, I venture to express myself, for myself. This is of course individualistic, subjective and often controversial. However, age permits retrospection and hindsight offers a comfortable armchair from which to look around. Age also brings about the dubious privilege of having one?s mistakes tolerated or forgotten (together with the author). Serendipity, empiricism and almost any branch of science have all contributed ? not necessarily in this sequence ? to what we now consider state of the art in oncology. Collaborative efforts in sometimes unrelated disciplines often bear unexpected fruit and only emphasize the need to keep trying.
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