An animal study suggests that the risk of metastasis depends on the phase of the estrus cycle when the cancer cells enter the circulation. In mice, dramatic differences in the organ specificity of extrapulmonary metastases was observed when cancer cells were injected during proestrus versus metestrus. One-third of the mice injected during metestrus developed ovarian metastases, while none of the mice injected in proestrus developed ovarian metastases.
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