CW October 2003

category image Volume 12
Issue Number 10
October 2003
ISSN 10593802

Inhibition of Tumor Growth by a Peptide Present in Cartilage

An important chemical constituent of cartilage is a protein called Hyaluronan Binding Protein (HABP). It has been found that HABPs inhibit tumor growth and angiogenesis. A 42-amino segment from HABP has been now been identified as the active region responsible for the antitumor activity. This region contains three repeats of the hyaluronan binding motif, which consist of a sequence of seven amino acids flanked by two basic amino acids.
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Source & Additional Reading

X.-M. Xu et al. A Peptide with Three Hyaluronan Binding Motifs Inhibits Tumor Growth and Induces Apoptosis. Cancer Research, September 15, 2003.

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