CW June 2003Issue Number 6 June 2003 ISSN 10593802 Monoclonal Antibody Trastuzumab does not Cross Blood-Brain BarrierWomen with HER-2/neu receptor-positive metastatic breast cancer respond very well to trastuzumab-based therapy. Trastuzumab is a monoclonal antibody directed against HER-2/neu receptors. However, patients treated with this antibody have a high risk of developing brain metastasis. One reason may be poor penetration of this antibody to cerebrospinal fluid.
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