Genes associated with tumor markers are rapidly becoming inflationary; the sequencing of the human genome, while explaining preciously little, has led to ?data-mining? and the deposition of thousands of Expressed Sequence Tags (EST) ? of both known and novel genes. Bioinformatics of the CGAP database led to the prediction (and later confirmation) of single minded genes and the sim2 gene was born: located at the minimum region of chromosome 21, it is readily implicated in the Down?s Syndrome Critical Region. This expression of sim-2 in selected, but not all solid tumors offers both diagnostic and therapeutic potential.
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