The family of multidrug resistance (MDR) proteins is slowly expanding to include nine members; their common link appears to be their membership in the ATP-binding cassette. They all use the energy from ATP hydrolysis to transport substrates across biological membranes, and usually have an excretory role that is indiscriminate ? or so it seems. MRP2 transports glutathione and various conjugates, drugs (including cancer chemotherapeutics, antibiotics, and uricosurics), toxins, and heavy metals. Its main clinical importance is its potential to modulate the pharmacokinetics of many drugs. As a reciprocal effect, various drugs, in turn, regulate the expression and activity of MRP2.
Go to Previous Page
Go to Next Page