Malignant growth in the oral cavity can be readily identified at its precancerous stages, which allows for early intervention. Despite this obvious opportunity, survival from oral carcinomas remains poor and incidence is still rising. Apart from inspection, there are no accepted markers for future aggressiveness and more often than not, definitive treatment is delayed. In an effort to improve this frustrating situation, an association between gross genomic aberrations and dysplastic leukoplakias (oral white patches) has been established. Abnormal DNA content, aneuploidy and centrosome defects have been found to predict the subsequent development of carcinomas.
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