The human genome project has generated enormous amounts of information, most of which is so far indigestible. Even the most complete sequencing is not a key to understand biological functions and processes. The expectations, fuelled by the press, were great and the possibilities seemed unlimited. Now we are entering a ?cooling of? period, in which we try to distinguish the known from the as yet unknowable. It has also become obvious that the predicted rapid drug discoveries and cure-alls have not been achieved from genome projects. A tortuous path runs from identifying DNA, its transcription into RNA to its translation into proteins and finally the delicate post-translational modifications into functional proteins by glycolysation and phosphorylation. This is where the need for proteomics begins.
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