Angiogenesis involves endo-thelial cell invasion and requires regulated cell adhesion and degradation of the extracellular matrix. Vascular invasion is facilitated by the binding of matrix metalloproteinase 2 (MMP2) to the integrin αVβ3 on endothelial cells. Researchers have discovered a novel organic molecule (called TSRI265) that blocks this protein-protein interaction and functions as a potent anti-angiogenic agent.
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