Currently, magnetic resonance imaging (MRI) scan to determine the size of the tumor is used to monitor response to therapy in brain cancer patient. However, reduction in volume of tumor following treatment is a slow process and failure of a therapy cannot be determined early enough to administer effective alternative therapies. A novel MRI technique, diffusion MRI, can detect the change in water diffusion values in tumor that is associated with cell kill of the tumor and precedes the change in tumor size. This is a very sensitive method and can be used as an early surrogate marker to determine the efficacy of a treatment in brain cancer patients.
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