Vascular Endothelial Growth Factor (VEGF, also known as vascular permeability factor) is the primary stimulant for the development and maintenance of a vascular network in embryogenesis and the vascularisation of tumors. After an initial period of cell proliferation, further continuous growth requires neo-angiogenesis: the growth of new vasculature sprouting from existing vessels or its formation from circulating endothelial cells. Inhibitors of such angiogenesis are a logical choice for successful cancer treatment. After much initial enthusiasm, the direct administration of antiangiogenic substances has not fulfilled the expectations, which does not rule out the rationale of this approach. VEGF is a vascular growth factor of major importance and requires recognition by receptors. The latter have become targets for interference with angiogenesis, using selective antibodies.
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