Survivin, another inhibitor of apoptosis, has been identified as one of the most important ?transcriptomes? expressed in common human cancers. So much is being written about the importance of apoptosis for the proper adjustment of the optimal cell numbers by programmed cell suicide that it suffices to say: in cancer, defects in apoptotic mechanisms facilitate the insurgence of additional cellular mutations by inhibition of their timely and efficient removal. Regulators of apoptosis, when selectively expressed in malignancy, become ideal candidates for tumor markers; since survivin can be determined in urine samples, it may become an excellent candidate for first-line diagnostic testing.
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