Cisplatin has become a widely used anticancer agent; its cytotoxicity is based on the ability to crosslink DNA. Especially high-mobility-group domain proteins are specifically attracted by hydrophobic cell structures and might mediate the antitumor efficacy of cisplatin. Eventually, cisplatin-resistance develops and is, at least in part, caused by increased nucleotide excision repair (NER) which interferes with the apoptotic pathway. Novel platinum compounds with increased hydrophobicity are being developed and show improved antitumor efficacy.
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