Cells become malignant after a cascade of mutations in several genes that control division, apoptosis or ability to migrate; therefore, the merit of genetic interference, if feasible, is unquestionable. For quite some time, ?Gene? therapy has been the topic of too much hype and too little success. In order to be effective, relevant genetic material must be introduced into the target cells and the expression of the transgene needs to be sufficient in quantity and duration. For now, gene transfer in hematopoietic cells is among the most widely used and is reasonably well understood, but is still far for realizing its full potential; nevertheless, stem cell-based gene therapy has a promising future in the potential cure of hematologic and other cancers.
Go to Previous Page
Go to Next Page