The ideal of cancer prevention is to develop and adhere to an optimal life style, which covers a wide range of environmental, nutritional and sexual factor together with the administration of chemicals and possibly of vaccine-like regimes. The goal is defined by a reduction in cancer incidence, based on the current rate of a specific cancer in a specific population. Such a preventive effect should last for a finite period of time to be statistically valid. In-numerable synthetic and natural substances have been proposed, hailed, tested and rejected. A recent task force on intraepithelial neoplasia (IEN), established by the American Associ-ation for Cancer Research, has submitted a document on ?Treatment and Prevention of IEN? to the US FDA; some proposals have been approved and will be briefly reviewed here.
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