Neuroblastoma is a childhood malignancy of the sympathetic nervous system, located in the adrenal glands. Even after initial response to chemotherapy, the majority of patients develop progressive disease that is increasingly unresponsive to treatment. Neuroblastoma cells are able to escape even intensive, marrow-ablative chemotherapy; it appears that during therapy, the tumor acquires a sustained high-level drug resistance. Better understanding of the mechanisms of this resistance would improve the fate of these patients after reinduction chemotherapy.
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