CW October 2001

category image Volume 10
Issue Number 10
October 2001
ISSN 10593802

Talented Twins

p16Ink4a and p19Arf might be considered to be molecular twins. They are born from the same genetic locus CDKN2A (INK4a/ARF) and have tricked biologists for some years about which one is important in preventing cancer. Now cancer biologists have nailed down this talented twosome and formally proved that both are critical for inhibiting tumorigenesis.
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by Jonathan B. Weitzman, Ph.D.

  1. Krimpenfort et al., Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.
    Nature 413, 83-86 (2001)
  2. Sharpless et al., Loss of p16Ink4a with retention of p19Arf predispose mice tumorigenesis, Nature 413, 86-91, 2001
  3. Kamijo et al., Tumor suppressor at the mouse INK4a locus mediated by the alternative reading frame product p19ARF, Cell 91, 649-659, 1997.

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