CW April 2002
Issue Number 4
PG-TXL, a Smart Pharmaceutical
Conjugation of paclitaxel with polyglutamate renders it easily available to tumor cells than normal cells because blood vessels supplying the tumors are more porous to the conjugate than the blood vessels supplying the normal tissues. Additionally, a proteolytic enzyme cathepsin B is present in significant amount in rapidly growing tumors that releases active paclitaxel from its conjugate in the tumor over a period of time maximizing its effect.
Go to Previous Page
Go to Next Page
Source & Additional Reading
S. Shaffer et al., 93rd Annual Meeting of the American Association for Cancer Research.
Purchase Downloadable Full-text PDF of Article: $10.00
Subscription is more cost effective than purchasing PDFs on-the-fly. Click here for details.
Download Complete Issue CW April 2002
Purchase Downloadable Full-text PDF of Complete Issue: $20.00
Adenine Press, 2066 Central Avenue, Schenectady, NY 12304 USA
Re-initialize IP-based Login