CW April 2002

category image Volume 11
Issue Number 4
April 2002
ISSN 10593802

PG-TXL, a Smart Pharmaceutical

Conjugation of paclitaxel with polyglutamate renders it easily available to tumor cells than normal cells because blood vessels supplying the tumors are more porous to the conjugate than the blood vessels supplying the normal tissues. Additionally, a proteolytic enzyme cathepsin B is present in significant amount in rapidly growing tumors that releases active paclitaxel from its conjugate in the tumor over a period of time maximizing its effect.
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Source & Additional Reading

S. Shaffer et al., 93rd Annual Meeting of the American Association for Cancer Research.

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